Galega officinalis

Galega officinalis, commonly known as goat's rue, French lilac, Italian fitch or professor-weed, is an herbaceous plant in the Faboideae subfamily. It is native to the Middle East, but it has been naturalised in Europe, western Asia, and western Pakistan. The plant has been extensively cultivated as a forage crop, an ornamental, a bee plant and as green manure.

Its name derives from gale (milk) and ega (to bring on), as Galega has been used as a galactogogue in small domestic animals (hence the name "Goat's rue"). Galega bicolor is a synonym. It is a hardy perennial that blooms in the summer months. Galega is used as a food plant by the larva of Coleophora vicinella, a species of moth.

Galega officinalis has been known since the Middle Ages for relieving the symptoms of diabetes mellitus. Upon analysis, it turned out to contain compounds related to guanidine, a substance that decreases blood sugar by mechanisms including a decrease in insulin resistance, but were too toxic for human use. Georges Tanret identified an alkaloid from this plant (galegine) that was less toxic, and this was evaluated in clinical trials in patients with diabetes in the 1920s and 1930s .

Other related compounds were being investigated clinically at this time, including biguanide derivatives. This work led ultimately to the discovery of metformin (Glucophage), currently recommended in international guidelines for diabetes management as the first choice for antidiabetic pharmacotherapy alongside diet and exercise, and the older agent phenformin, which has been withdrawn in most countries due to an unacceptable risk of lactic acidosis (the risk of lactic acidosis with metformin is no higher than with other antidiabetic therapies when it is prescribed according to its label).

The study of galegine and related molecules in the first half of the 20th century is regarded as an important milestone in the development of oral antidiabetic pharmacotherapy.




Source: http://en.wikipedia.org/wiki/Galega_officinalis



See Also: Bouquet, Roses, Floral